A simple high performance liquid chromatography (HPLC) assay for aciclovir and ganciclovir in serum
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High-performance liquid chromatography (HPLC) assay for ribavirin and comparison of the HPLC assay with radioimmunoassay.
The use of high-performance liquid chromatography (HPLC) to measure ribavirin in serum and other biological fluids has been limited by endogenous interfering substances. We report an HPLC procedure based on the extraction of ribavirin from serum, plasma, or cerebrospinal fluid with a boronate affinity gel, which uses a 3-methylcytidine internal standard. This assay is sensitive (to 0.4 microM),...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1996
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/38.4.739